The purpose of the fellowships is to promote exchanges between European Laboratories and Clinical Services. As a result of those exchanges, new technologies may be learned and, whenever possible, lasting partnerships may be developped. Yearly since 1993, the Foundation's Scientific Board has been reviewing candidate applications and allocating the following fellowships: * One fellowship of 18000 * Four Fellowships of 4500

2006   François DURUPT Développement et évaluation pré-clinique de vecteurs adénoviraux oncolytiques ciblés et armés pour le traitement du mélanome humain métastatique. Florence MASSON Thymic stromal lymphopoietin in Allergy. Eva MURAUER Optimizing trans-splicing based gene therapy for patients suffering from recessive dystrophic epidermolysis bullosa. 2005   Lionel LARRIBERE Endoplasmic reticulum stress-associated responses in melanoma initiation and maintenance. Irena L. ANGELOVA-FISCHER Chemokine and cytokine profile and kinetics of release following acute epidermal barrier disruption in in vitro and in vivo experimental models. Delphine JAVELAUD Implication de la voie de signalisation du TGF-ß dans le développement du mélanome. Tomomi KIMURA Investigation of function of PKC in regulation of desmosomal adhesiveness during embryonic epidermal development Giuseppe STRINATIZ The interaction between alpha5beta1 integrin and soluble vascular endothelial growth factor receptor-1 in the wound healing process. 2004   Jean-David BOUAZIZ Expression et fonction de KIR2DL4 dans le syndrome de Sézary : création d’un modèle d’immunothérapie par un anticorps monoclonal anti-KIR2DL4 chez la souris SCID Alain DUPUY Analyse différentielle du profil d’expression transcriptionnel sur des lignées cellulaires du mélanome Ondrej MALEK Spontaneous tumoral regression: molecular analysis in a swine model of hereditary. Huu Sau NGUYEN Influence du microchimérisme foetal sur la formation et l’évolution des mélanomes maternels pendant la grossesse. Belen RODRIGUEZ SANCHEZ Cell migration and signalling in 3D collagen I matrices. 2003   Tobias W. FISCHER Antioxidative role of melatonin in human skin biopsies. Jean-Pierre HACHEM Functions of stratum corneum acid mantle in mammalian skin. Damien PICARD Analysis of gene transcription by DNA chips in the drug hypersensitivity syndrome. Kaisa TASANEN Deletion of collagen XVII shedding region by specific gene targeting in mice. Xin XU Molecular analysis of skin diseases involving the NF-kB signaling pathway. 2002   Clara Ibel CHAMORRO The role of human antimicrobial peptide LL-37 in skin re-epithelialization. Sophie DE SCHEPPER The role of neurofibromin, gene product of the NF1 gene, in proliferation and differentiation of normal human melanocytes. Alexander V. KOUZNETSOV Identification of T cell-receptor-a and b-chain rearrangements of pathogenic psoriatic T lymphocytes as a condition for creating recombinant T cell-receptors. Homayoun MOSLEHI The mechanism of keratinocyte apoptosis in TEN (Lyell syndrome). David PEARTON Adult epithelial plasticity : the ability of differentiating corneal epithelial to give rise to an epidermis and associated stem cells. 2001   Paul KHOSROTEHRANI Role of microchimerism in human pathology. Christine BALDESCHI Phenotypic reversion ex vivo of keratinocytes from patients with dystrophic epidermolysis bullosa : biochemical and immunological studies of recombinant collagen VII. Niina REUNANEN TGFb signal transduction in dermal vs. Gingival fibroblasts. Towards the elucidation of molecular mechanisms of scarring. Florian WEBER The roles of TGFb1 and MIC-1 in anti-tumour immunity. 2000   Nikhil YAWALKAR Characterization of T cells in psoriasis.. Stéphanie HENRIOT Study of the activation of OVA 323-339 specific T lymphocytes by methylated analogues of OVA 323-339. Martin MEMPEL Identification of NKT-cell recruiting mechanism in glycolipid induced cutaneous granulomas. Karina PHILIPS Characterisation of T lymphocytes-mediated allergy to amoxicillin. Silvia SANCHEZ-RAMON Identification and characterisation of new tumour-associated antigens from melanoma derived-exosomes. Meinhard SCHILLER Evaluation of the effects of a-MSH on (1) TGF-b-induced Smad signaling and (2) type I collagen gene (COL1A2) expression in (a) cultured human dermal fibroblasts and (b) fibroblasts derived from fibrotic skin lesions. 1999   Stephanie BEHRENS Investigation on the effect of UV light on the epidermis of healthy volunteers and vitiligo patients using FT Raman Spectroscopy and Differential Display RT-PCR. Jean-Eudes DAZARD MDM2-p53 regulation loop in epidermal keratinocyte differentiation. Edda FIEBIGER Analysis of proteases involved in MHC class II processing and antigen degradation in Langerhans cells of the skin. Farhad HANDJANI Characterization of dendritic cells in cutaneous leishmaniasis. Yi LU Identifying differences in mRNA expression in fibroblasts of psoriatic patients according to cell-cell and cell-matrice interactions. Nadem SOUFIR Study of P16INKA gene expression and methylation on skin tumours. Laurence VINDEVOGHEL TGF-b signaling mediated by SMAD molecules. 1998   Frédéric BERARD To participate to a research program on in vivo induction of antitumoral immune response by autologus dentritic cells activated in vitro by exposure to melanoma antigens. Luca BORRADORI To acquire the molecular biological technique "Yeast Two Hybrid System". Malika BOUKHELIFA Role of laminine interactions with its integrins receptors in formation of focal adhesion contacts and signal transduction. Denis MARTINVALET Characterization of antitumoral response in human cutaneous T lymphoma cloning of tumural antigens. Maryline ALLEGRA Functional study of the 400 kDa form of laminin-5 by inactivating in mouse proteolytic clivage site in the delta-2 chain of laminin-5 by homologous recombination ("knock-in"). Nanny A. C. van GEEL To participate in a research program on the involvement of cytotoxic T-cell responses in marginal skin of active vitiligo and to acquire techniques of culturing autologous melanocytes and mixed melanocyte/keratinocyte cell suspensions suitable for transplantation. Dr Kyril TURPAEV Nitric oxide dependent regulation of transcription factors and activation of gene expression in fibroblasts and keratinocytes. Jacques ZIMMER - Study of receptors activators of NK cells in patients deficient in HLA molecule expression - Phenotype and function of NK cells clones from these patients. 1997   Isabelle LEBLOND   To acquire knowledges in molecular biology and specially in the cloning of antigen T receptors. Olivier DEREURE  Study of tumor suppressor genes and apoptosis genes in T cutaneous T lymphoma. Rolph PFUNDT  Expression in psoriasis of specific genes like SKALP, cytokeratins 6, 16 and 17. Christine ROMERO-GRAILLET  Contribution à l'identification du récepteur cellulaire du Papillomavirus. Simone SEITER Assessment of the immune response of melanoma patients treated with anti-idiotypic monoclonal antibodies. Nicolas DUPIN Caracterisation and expression of possible oncongenic genes of HHV 8 virus in the Kaposi sarcoma Sandrine CHARVAT Quantitative study of mRNA of the matrix metalloproteases expressed by normal human keratinocytes compared to keratinocytes lines. Howard STEVENS To perform linkage studies in a number of different genodermatoses.   Jens Michael JENSEN Role of involucrin in barrier function in a transgenic involucrin knockout mouse model. 1996   Enikö WENCZL This research project is part of a more extensive project granted by tbe Dutch Cancer Foundation concerning the genetic toxic effect of UV-radiation on human skin cells in relation to their red-yellow (pheo) - andbrown-black (eu) melanin levels.The main question of the project is whether melanin is photoprotective or it is eventually photosensitizing. The relevance of the project is to get more insight into the role of the mentioned melanin types in human photoprotection. Eric DONOIS Quantification of intracellular melanin by transmission electron microscopy image analysis. Dirk LANGE Apoptosis, expression pattern of TGF-ß, its receptors and PCNA in normal, injured and tumorous skin. Stéphane CHAVANAS Identification of mutations in patients with different forms of epidermolysis bullosa. Reza GHOHESTANI Characterization of a 168 kDa new antigen of dermo epidermic junction. Anne Sophie CHARBONNIER Infection by HIV of Langerhans cells generated in vitro and consequences on their function of antigen presenting cells. Frédérique-Marie RATTIS Role of "Macrophage Stimulating Protein" (MSP) on mobility and activation of murine epidermic Langerhans cells. 1995   Rozen LE PANSE Analysis of calreticulin in human epidermal keratinocytes. Pierre BUFFET Treatment of cutaneous leishaniasis : clinical expression of molecular mechanism of parasite-resistance. Klaus DEGITZ Oligonucleotide-directed photo induced inhibition of ICAM-1 gene expression. Pierre-André BECHEREL Mr Becherel works on inflammatory activation of human keratinocytes and wishes to study on Pr Moncada Laboratory's the role of nitric oxide synthase in keratinocytes. Caroline ROBERT In vitro study of the production of factors responsible for ageing by keratinocytes or dermal cells and identification of these factors. Philippe ANDRES Morphometric evaluation of children melanocyticmaevus by automatic computerized analysis, associated with histologic study and epiluminency. Laurent CAGNOUX Role of laminin-5 and integrin ß-4 in hemidesmosome structuration. Frédéric CAUX Characterization of epitopes recognized by cicatricial pemphigoid autoandibodies on the BP180 ectodomain. 1994   Christophe BEDANE To acquire immunogold postembedding technique. This project is part of research subject continuation on immunobullous disaders of dermo epidermic junction. Anne BOULOC Study of messenger RNA synthetis by epidermal cells after contact with an hapten. Modulations by physical and chemical agents. Corine FERRARIS Study of epidermic structures differentiation under influence of associated-fibroblasts. Acquisition of new techniques for its laboratory of origin. Denis JULLIEN Leprosy and immune responses factors determining TH1 vs TH2 cytokine production. 1993   Barbara GAYRAUD Influence of external factors on type VII collagen synthesis and on formation of anchoring fibrils in skin equivalent cultures. Corrine MOULON Molecular approach of mechanism involved in nickel-induced contact sensitivity in humans. Patricia ROUSSELLE Characterisation of a novel protein of the dermal-epidermal junction : kalinin - study of its biological functions. Joëlle VAILLY Identification of mutations in nicein genes in patients with the Herlitz's syndrome. Albert RUBBEN HLA-Class II allelic variation and susceptibility to cutaneous infections with Human Papillomaviruses.